Scientist/Senior Scientist, Immunology

NewLimitSouth San Francisco, California, United States · Posted 6 months ago

Full-timeEst. 155,000 USD

Description

About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

NewLimit is seeking a highly motivated Scientist/Senior Scientist in Immunology to lead and execute key discovery-to-preclinical research efforts in inflammatory and autoimmune diseases, with a strong emphasis on T cell and regulatory T cell (Treg) biology. This role will design and implement in vitro screening assays to support lead selection and contribute to preclinical efficacy, safety, and mechanism-of-action studies. You will work closely with cross-functional partners to support program advancement toward IND-enabling studies.

What you'll do

In your role as a Scientist, you will:

Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and evaluate epigenetic reprogramming interventions for aged T cells, including integration and interpretation of complex, multi-modal datasets
Develop scalable functional assays in T cells and Tregs to predict therapeutic activity and inform lead selection
Design and lead in vivo and in vitro immunology studies to support target discovery, validation, and preclinical development
Contribute deep expertise in inflammatory and autoimmune disease biology to experimental design and data-driven program strategy
Drive research in Treg biology, including differentiation, stability, and suppressive function
Author or contribute to study reports, internal data packages, and regulatory-supporting documentation
Mentor junior scientists and foster a collaborative, rigorous scientific culture
Present data, analyses, and scientific recommendations clearly to internal teams and leadership

Requirements

Ph.D. in immunology, cell biology, or a related field or BS/MS with 6+ years of relevant industry experience
Hands-on experience with multi-parameter flow cytometry
Experience designing in vivo models of autoimmune or inflammatory disease
Experience with primary immune cell isolation, ex vivo culture, and Treg functional assay

Nice to have

Experience with pooled in vitro or in vivo screening approaches using bulk or single-cell readouts (e.g., CRISPR fitness screens, Perturb-seq, CROP-seq)
Experience with rheumatoid arthritis and/or colitis models
Experience authoring IND-supporting study reports
Experience managing or partnering with CROs to support preclinical studies, including alignment on study design, timelines, and data quality
Familiarity with basic computational tools for data analysis (e.g., Python, R)

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
Meals and snacks on-site

Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.