Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)
AlumisSan Francisco, California, United States · Posted Oct 25, 2024Description
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.
The Alumis team seeks a highly motivated Director in autoimmune discovery biology. The candidate should be well-versed in small molecule drug discovery and bring experience with a variety of target classes and modalities. The individual will take responsibility for important project-level biochemistry and biology efforts advancing our early portfolio of small molecule autoimmune therapies, as well as mentoring junior staff. The ideal candidate will bring expertise drawn from different areas of biology and immunology, such as biochemistry, pharmacology, cell biology, molecular biology, and chemical biology/proteomics. Prior experience will ideally span across the stages of drug discovery from lead finding through early clinical development.
Key Responsibilities:
- Taking biology department responsibility in discovery-stage small molecule projects including conceptualizing project strategy, recognizing knowledge gaps, formulating screening paradigms, overseeing SAR generation, coordinating among project stakeholders, and identifying potential new targets
- Overseeing development of both biochemical and cellular read-outs to support small molecule drug discovery efforts Support characterization of small molecule clinical candidates by employing autoimmune disease models and developing clinically relevant PD assays
- Providing both direct and indirect supervision of laboratory-based biology staff
- Manage external biology studies performed at CROs.
- Collaborating effectively with cross-functional teams including medicinal chemistry, DMPK, and preclinical development.
- Ensuring effective communication and coordination with departmental and company-wide leaders on project strategy and progress toward goals
Ideal candidate:
- PhD with 8+ years biopharma work experience in immunology-related small molecule drug discovery
- Prior experience with function-level oversight of project biology and/or biochemistry efforts, or overall project team leadership
- Knowledge of and hands on experience with emerging areas of small molecule drug discovery, such as protein-protein interaction inhibitors, degraders and molecular glues, and transcription factors
- Expertise spanning from early-stage target discovery and validation through early clinical development
- Awareness of methods for compound screening, characterizing mechanism of action, transcriptomics, and proteomics
- Familiarity with autoimmune disease biology including in vitro and in vivo immunology models, immortalized cell lines, isolation and characterization of primary immune cells, RNA-Seq, and cytokine detection methodologies
- Prior management of CRO collaborations, with an existing familiarity of a wide variety of biology CROs
- Excellent interpersonal skills with the ability to work both independently and cross-functionally to advance drug discovery programs; experience working with academic collaborators is a plus.
- Successful direct and indirect supervision of junior staff members
- Familiarity and enthusiasm for working in a small company environment
- Track record of scientific achievement and innovation
The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices.
Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.
Other benefits include:
- Health insurance premiums paid at 90% for employee, 80% for dependents
- Free access to Genentech Bus & Ferry Share program
- $100 monthly cell phone stipend
- Unlimited PTO for Exempt employees
- Free onsite gym and a kitchen stocked with yummy snacks and drinks!
We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.
Alumis Inc. is an equal opportunity employer.
Similar jobs
Est. 220,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 154,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 150,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 287,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 329,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 317,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 350,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 123,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 342,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 170,950 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 217,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 215,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 220,000 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 232,500 USD
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic condition…
Est. 130,000 USD
At Alamar, we are passionate about enabling our customers to make scientific discoveries that translate into clinical outcomes and benefit patients. Our team is growing quickly as we develop innovative approaches to meas…
Est. 155,000 USD
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and a…
Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have th…
Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have th…
Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have th…
Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have th…
Est. 277,750 USD
About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and i…
Est. 200,000 USD
Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, suppor…
Est. 208,178 USD
Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, suppor…
Est. 124,600 USD
Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at altosla…
Est. 214,000 USD
What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way. What this position is all about: What if you…
Est. 176,945 USD
Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, suppor…
Est. 120,000 USD
Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, suppor…
Est. 215,000 USD
At Alamar, we are passionate about enabling our customers to make scientific discoveries that translate into clinical outcomes and benefit patients. Our team is growing quickly as we develop innovative approaches to meas…
Est. 235,000 USD
About Beeline Medicines: Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and i…
Est. 219,500 USD
Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that…