Sr Scientist, Antibody Discovery
Twist BioscienceQuincy, Massachusetts, United States · Posted 2 months agoDescription
Sr Scientist, Antibody Discovery (onsite in Quincy, MA)
Job Description
This is an individual contributor role that provides support for bioanalytical characterization for a variety of assays critical for characterizing therapeutic antibody candidates. This role will work closely with our Antibody Characterization and Protein Analytics team at our Quincy, MA location and is responsible for analyzing, optimizing, and troubleshooting a range of workflows, including SPR and BLI affinity analysis, developability assays, flow cytometry, functional assays, and target binding characterization.
What You’ll Be Doing:
- As an individual contributor Senior Scientist, you will support members of multiple scientific teams as a Project Lead, but will not directly manage team members.
- Guide multiple projects per day to ensure scientific excellence and execution for antibody projects involving binding affinity determination (SPR, BLI) and developability assays (i.e. aSEC, CIC, HIC, BVP-ELISA, AC-SINS, plate-based off-target assays, DLS, and nanoDSF) for a variety of antibody and biologics formats (IgG, VHH, Minibinders, etc.)
- Assist cross-functionally with the wet lab teams, Project Management team and scientific leaders across multiple sites within the company to ensure exquisite execution of individual projects, while also providing guidance for future assay integration and improvement in the antibody discovery workflow.
- Provide technical guidance (assay development, analysis, and data reporting) for antibody-based projects in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), developability assays, advanced/custom characterization, and functional screening.
- Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
- Review, critically analyze, and present data to customers for a variety of concurrent antibody discovery programs.
- Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
- Spend time performing wet-lab benchwork alongside the team based on workflow and assay development needs. It is anticipated that the role would involve an 80/20 split of analysis vs wet lab time.
What You’ll Bring:
- Strong knowledge of antibody and biologics characterization is required.
- Previous experience with Carterra SPR systems, Octet BLI, and/or developability assays (HPLC and high throughput plate-based) is required. Further direct experience is expected with ELISA, SDS-PAGE, protein quantification, and endotoxin assays.
- Experience in high-throughput assays (1,000s of samples) is preferred.
- Ability to troubleshoot scientific processes, make sound scientific decisions on tight timelines, and accurately analyze and report data with utmost attention to detail.
- Ability to work simultaneously on multiple workflows, prioritizing effectively.
- Effectively communicate project updates, risks, and progress to the manager and cross-functional team members in a timely and professional manner.
- Actively participate in team meetings, clearly articulating needs, concerns, and proposed solutions to drive efficient collaboration.
Requirements
- PhD in a related technical field with 5+ years of experience in biopharmaceutical analytical development or master's in a. related technical field with 10+ years of experience
- Expert knowledge of antibody biologics characterization assays: extensive hands-on experience required in Carterra SPR, Octet BLI, ELISA, flow cytometry, and antibody developability characterization.
- Advanced understanding of in vivo antibody discovery concepts.
- Strong track record of developing, executing, and analyzing common assay formats for antibody discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
- Demonstrated capability to work autonomously, prioritizing responsibilities within a high-pressure setting characterized by concurrent projects and time-critical workflows.
- Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
- Exceptional written and verbal communication skills, including external customer-facing communication.
- Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.
About Twist Bioscience
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
The base cash compensation for this Massachusetts-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.
Similar jobs
Est. 206,000 USD
Sr. Staff Scientist - Protein Sciences R&D (Onsite in South San Francisco, CA) Summary Twist is searching for an exceptional R&D scientist with experience in cell biology and protein expression and purification,…
Est. 85,000 USD
Research Associate II, Upstream Antibody Discovery Job Description We seek a Research Associate to support in vivo antibody discovery using ourhigh-throughput hybridoma process. In this lab-based role, attention to detai…
Est. 206,500 USD
Sr. Manager - Protein Sciences R&D (South San Francisco, CA) Summary Twist is searching for an RnD scientist/manager with experience in cell biology and protein expression and purification, with an emphasis on antibo…
Est. 145,000 USD
The Sr Business Development Manager, Antibody Discovery Services will work to establish Twist’s market position for the Biopharma discovery services group. Developing strategic goals, building key customer relationships,…
Est. 144,500 USD
Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologist…
职位概述 该职位需要一位兼具深厚技术背景与出色沟通能力的专家。您将成为连接公司产品与客户成功之间的关键桥梁，为中国区的客户提供NGS panel设计，synbio相关产品的售前售后全方位、深层次的技术支持。您不仅需要具备深厚的生命科学背景知识和一定的生物信息学知识，还需要解答产品问题，成为基础科研客户和工业客户（包含抗体开发、细胞治疗、基因治疗及AI药物开发等领域）中的可信赖顾问，通过专业的技术方案解决实际难题，提升客户满意度与忠诚度。…
Est. 85,000 USD
Join our dynamic Talent Acquisition (TA) team as a Talent Acquisition Operations and Analytics Specialist. This critical role manages the TA technology stack, ensures data integrity, and uses recruiting metrics to provid…
Est. 172,000 USD
The Staff Product Manager will be responsible for all aspects of product management for Twist Bioscience Protein Solutions product portfolio. This includes assessing and prioritizing customer and market requirements, wor…
Est. 55,000 USD
We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations team in Wilsonville, OR. The Manufacturing Associate will produce various DNA and plasmid products, focusing on molecular and…
Est. 145,500 USD
About Genetix Biotherapeutics At Genetix Biotherapeutics every role has meaning, every team member is respected, and every day is a chance to make a difference. When you join Genetix, you're not just landing a new role,…
Est. 125,000 USD
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA…
Est. 55,000 USD
We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations team in Wilsonville, OR. The Manufacturing Associate, IgG Production, will produce various IgG antibody products, focusing on…
Est. 124,000 USD
Sr. Systems Engineer (Onsite in Wilsonville, OR) Summary We are seeking a Senior Systems Engineer to join our team in Portland, OR (PDX). In this role, you will lead the development, validation, and integration of cuttin…
Est. 23,100 USD
We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations Team in South San Francisco. The Manufacturing Associate, NGS TE will perform basic molecular biology workflows in a highly a…
Est. 325,000 USD
Twist Bioscience is seeking a visionary and highly accomplished leader to lead our global marketing organization, define our brand narrative, and drive sustainable, significant growth across all business units. The Senio…
Est. 207,750 USD
Position Summary: Quotient is seeking a Director or Senior Director of Antibody Discovery. This role will define and lead Quotient’s antibody discovery strategy; leading the delivery of therapeutic antibody projects in a…
Est. 207,750 GBP
Position Summary: Quotient is seeking a Director or Senior Director of Antibody Discovery. This role will define and lead Quotient’s antibody discovery strategy; leading the delivery of therapeutic antibody projects in a…
Est. 132,500 USD
The Next Generation Sequencing Sales Specialist is responsible for delivering revenue and driving growth in their territory for Twist Bioscience sequencing products. (S)he is accountable for delivering accurate revenue f…
Est. 243,500 USD
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clini…
Est. 121,250 USD
Salesforce SOX Compliance & Release Manager (Hybrid in South San Francisco) Summary The Salesforce SOX Compliance & Release Manager will maintain and execute our Sarbanes-Oxley (SOX) and Information Technology Ge…
Est. 191,000 USD
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress…
Est. 219,500 USD
Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that…
Est. 140,000 USD
About GenScript Founded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop groundbreaki…
About GenScript Founded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop groundbreaki…
Est. 140,000 USD
Sr Manager, Process Optimization & Industrial Engineering (onsite in Wilsonville, OR) Job Description The Sr. Manager of Industrial Engineering & Process Optimization will drive continuous improvement across high…
Est. 132,000 USD
We are looking for a Sr Global Product Marketing Manager to be responsible for planning, developing, and executing on marketing programs and activities for our organization. The ideal candidate will have a background wit…
Est. 110,000 USD
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA…
Est. 60,000 USD
The Inside Sales Specialist is responsible for successfully positioning and selling company products professionally and creatively in a given geographical region. The job involves a significant knowledge in lead generati…
Est. 140,000 USD
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA…
We are looking for passionate customer support representatives to join our rapidly expanding team. You will be responsible for delivering concierge-level, white glove support to our customers and differentiating Twist Bi…